While no number is more likely to win, there are clearly ways to pick better numbers. You want to pick your numbers randomly. Why? If you choose your numbers randomly, you have a smaller chance of matching other people. Only 70 percent of the participants use "Quick Pick" to purchase their tickets, which means that the remaining 30 percent pick their numbers in some other way (such as off of fortune cookies). Because these people do not usually pick truly random numbers, these 30 percent are more likely to have identical tickets, and if they win, they would have to share the jackpot with each other. If you think you might win, you'll want the jackpot to yourself, so you'll want to pick your numbers randomly.